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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are typically described by their focus on practical aspects of design, including the recruitment and consent process, as well as adherence and the use of standard equipment.
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A pragmatic study that involves different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for practical trials to be valid and also reduces the chance of bias in the results. However excessive heterogeneity could result in issues with the design of the trial.
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The goal of pragmatic trials is to simulate real-life situations and achieve the highest level of validity externally. They are typically commissioned by practitioners and policy makers to inform their decision making. They can also be used to assess the causal relationship between an intervention and its results. However, they shouldn't be used as a substitute for explanation trials.
The pragmatism concept is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study which includes recruitment, design, implementation of the intervention and its follow-up.
There is a positive trend in the number of pragmatic trials that are published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs), 프라그마틱 슬롯 사이트 무료 프라그마틱체험 메타 - Bookmarkhard.Com - yielded 34 articles, as shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. However, it is important to note that the majority of these studies were conducted in primary care settings.