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Pragmatic trials are those that are designed to inform real-world clinical practice. They are typically described as a focus on the practical aspects of designing a study which include recruitment and consent, adherence and the use routinely available equipment.
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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. However, too much heterogeneity can cause issues with the design of the trial.
Pragmatic Play is one of the biggest players on the live casino market, offers an array of traditional table games like Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta provide customers with an authentic experience in gambling as well as a broad range of virtual betting options. The company has also created various interactive games to make gambling online enjoyable. Some of these shows have live hosts, whereas others are hosted by prominent personalities from the industry.
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Pragmatic Play offers not only mobile-friendly slot machines, but also live casino and table games. The company is licensed by several regulatory bodies such as Malta Gaming Authority and UK Gambling Commission. The games offered by the company are protected by high-end encryption and its security staff is available to assist players in any situation.
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Legality
Pragmatic Play is known for its top-quality games and also for providing an outstanding user experience. Its software is accessible on mobile devices and in a variety of languages. It has been recognized as one of the most popular casino gaming platforms despite its relative youth. The most recent releases include Wolves 5 reel video slot that has a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They are also a good method of determining the causality between an intervention and its outcomes. However, they should not be used to replace explanatory studies.
The pragmatism idea is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis and pragmatic trials that inform the policy and practice of. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the features of a practical trial, including the recruitment process, the design and implementation of the intervention, as well as the follow-up.
The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the issue of pragmatic thinking. It is important to remember that the majority were conducted in primary-care settings.