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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often focused on practical aspects of the study design, including recruitment and consent in adherence, as well as the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and included participants from different geographical regions. This kind of heterogeneity, that is crucial for a pragmatic trial to be reliable and to reduce bias in the results, is also necessary. Too much heterogeneity, however can result in problems with the design of the trial.

Pragmatic Play is also a major player on the live casino market, providing a wide selection of classic table games such as Blackjack and Roulette in a variety of versions. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic experience in gambling as well a full variety of betting options via virtual. The company also offers a variety of games that make online gambling exciting and interactive. Some of these shows have live hosts, whereas others are hosted by famous personalities from the industry.

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Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. Its software is designed to work on mobile devices and is compatible with different languages. Despite its infancy it has established itself as a leading gaming platform for casinos. Wolves is one of its latest releases that is a 5-reel slot machine with a hefty RTP and stunning graphics. Its other notable titles are Wolf Gold and 프라그마틱 슬롯 무료 무료스핀 (Carpcloud22.bravejournal.net) Chilli Heat.

The purpose of pragmatic trials is to simulate real-life scenarios and gain maximum credibility externally. They are usually ordered by policymakers and practitioners in order to guide their decisions. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. However, they should not be used to substitute for explanation trials.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials can replace tests for explanations or if they are an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the validity of a clinical or physiological hypothesis as well as pragmatic trials, which guide the policy and practice of. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic research study that includes recruitment, design, delivery of the intervention and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs) produced 34 articles, shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority of studies were conducted in primary-care settings.