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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are often characterized by a focus on practical aspects of the study design, such as the recruitment and 프라그마틱 슬롯 무료 공식홈페이지 [click the next web page] consent process as well as adherence to the use of routinely available equipment.
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A pragmatic study that involves various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for pragmatic trials to be reliable and to reduce bias in the results is also essential. However, too much heterogeneity can lead to issues with the design of the trial.
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The purpose of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. Usually, they are ordered by policymakers and practitioners in order to guide their decisions. They can be used to determine the cause-effect relationship of an intervention with its outcomes. They should not, however, be used to replace explanation studies.
The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial which includes recruitment, design and delivery of the intervention, as well as follow-up.
The number of pragmatic trials is increasing. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of these trials were conducted in primary care settings.