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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often focused on practical aspects of the research design, like the recruitment process and consent as well as adherence to the use of routinely available equipment.
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Pragmatic Software, a software firm provides a variety of casino games on online gambling platforms. Pragmatic's iGaming solutions are utilized by the leading operators and casinos with a physical location. The company offers front-end site design tools, analysis tools and promotions, marketing security payment systems, customer service, and bug reporting. In addition, the company provides its players a secure environment that features high-quality graphics and gameplay.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and included participants from different geographic areas. This kind of heterogeneity is required for practical trials to be valid and helps to reduce the chance of bias in the results. However excessive heterogeneity could result in issues with the design of the trial.
Pragmatic Play is also a major player on the live casino market, providing an extensive selection of table games that are classic such as Blackjack and Roulette in various versions. The live studios of the company in Romania and Malta offer customers an authentic experience in gambling as well as a broad range of virtual betting options. The company has also developed numerous interactive game shows that make online gambling enjoyable. Some of these shows are broadcast live and some include famous people from the industry.
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Pragmatic Play is a new player in the online casino industry, but it has established itself through its mobile-friendly slot machines. Their games are optimized for mobile phones, and run on HTML5 technology. They are also licensed and regulated by reputable gaming authorities, ensuring fairness and transparency. This is a positive indicator for players, since it means that the games have been examined and verified to make sure that the results of each round are random and unbiased.
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Legality
Pragmatic Play is renowned for its top-notch games, and for offering an exceptional user experience. Its software is accessible on mobile devices as well as in various languages. It has been recognized as one of the top casino gaming platforms despite its relative infancy. The latest releases include Wolves which is a five-reel video slot that has a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.
Pragmatic trials seek to replicate real-world situations and have the highest external validity. Usually, they are commissioned by policymakers and practitioners to inform their decisions. They can also be used to assess the cause-effect relationship of an intervention and its effects. They should not, however, be used to replace explanation studies.
The idea of pragmatism is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials that inform the practice and policy decisions. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial that include recruitment, design and delivery of the intervention, as well as the follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) produced 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority of studies were conducted in primary care settings.