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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often described by their focus on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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A pragmatic study that involves different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for 프라그마틱 무료슬롯 pragmatic trials to be valid and to reduce bias in the results, is also necessary. A high degree of heterogeneity, however, can cause problems with the design of the trial.
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The goal of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. They are typically requested by practitioners and policymakers to help inform their decisions. They can be used to determine the causal relationship between an intervention with its outcomes. However, they shouldn't be used as a substitute for the use of explanation trials.
The concept of pragmatism is controversial and there are concerns regarding whether pragmatic trials could be used to replace explanation tests or if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis as well as pragmatic trials that inform the practice and policy decisions. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the features of a pragmatic study which includes recruitment, design and delivery of the intervention, as well as the follow-up.
The number of pragmatic trials is growing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority were conducted in primary care settings.