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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are usually focused on practical aspects of the research design, like the recruitment process and consent as well as adherence to the use of commonly available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from different geographical regions. This type of heterogeneity, which is vital for pragmatic trials to be reliable and lessen the chance of bias, is also necessary. A high degree of heterogeneity, however could cause issues with the design of the trial.
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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually requested by practitioners and policymakers to inform their decisions. They are also a good method of determining the causality between the intervention and 프라그마틱 불법 프라그마틱 슬롯 무료체험 (socialbookmark.stream) its effects. They should not, however be used to replace the need for explanation studies.
The idea of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the clinical or physiological hypothesis as well as pragmatic trials that inform policy and practice decisions. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial, including the recruitment process, the design and delivery of the intervention, as well as the follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health science community is becoming more acquaint to the subject of pragmatics. It is important to remember that the majority of these studies were conducted in primary care settings.