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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described by their focus on practical aspects of design which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from different geographical regions. This kind of heterogeneity is required for pragmatic trials to be able to prove their validity, and 프라그마틱 정품 사이트 it also helps to reduce bias in the results. However, too much heterogeneity can lead to issues with the design of the trial.
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Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are typically commissioned by policy makers and practitioners to guide their decision-making. They can also be used to determine the causality of an intervention and its results. However, they shouldn't be used to substitute for explanatory trials.
The idea of pragmatism is controversial and there are doubts regarding whether pragmatic trials could be used to replace explanation tests or if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate a physiological or clinical hypothesis as well as pragmatic trials, which inform policy and practice decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the characteristics of a pragmatic trial which includes the recruitment process, the design and delivery of the intervention, and monitoring.
There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health sciences community is becoming more acquaint to the issue of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.